No effective pharmacological treatment for gluten-related disorders exists to date. AMYRA is here to fix that.

The Pathologies

Celiac Disease

Overview: Celiac Disease

Celiac disease is an autoimmune disease which is caused by a GIP-induced activation of the adaptive immune system in genetically predisposed individuals. The immune reaction mainly takes place in the small intestine, where an inflammation results in acute symptoms such as chronic diarrhoea, bloating, vomiting, and abdominal pain. Furthermore, the damage wrought upon the body’s organs and tissues by this chronic inflammatory condition can lead to more malignant complications such as malnutrition, osteoporosis, and gastrointestinal cancer.

Prevalence

1% – 1.5%

Number of individuals affected globally​

> 0 m

Non-celiac gluten sensitivity

Overview: Non-Celiac Gluten Sensitivity

Non-Celiac gluten sensitivity is a clinical syndrome that is distinct from celiac disease and wheat allergy. It is characterized by the expression of intestinal and extra intestinal symptoms (imminently) following the ingestion of gluten or other components of wheat. Common symptoms include abdominal pain, bloating, diarrhea and systemic manifestations such as ‘foggy mind’, headache, fatigue, depression and anemia.

Prevalence

6% – 10%

Number of individuals affected globally​

> 0 m

Gluten-free diet

A gluten-free diet is the nutritional therapy implemented upon diagnosis of celiac disease or non-celiac gluten sensitivity. To date, it is the only method by which patients can avoid severe symptoms, since no effective pharmacological treatment exists. Although a gluten-free diet is beneficial, it is difficult to maintain and patients often do not achieve histological remission due to continued unintentional gluten intake. The average inadvertent consumption of gluten by celiac patients on a GFD was estimated to be between 150 and 400 milligrams per day. This is 7-20x higher than what experts deem to be non-immunogenic.

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